The hippocampus and its small subregions are areas of the brain that play an integral role in memory. Our study leveraged new brain imaging methods to study these small subregions and their relation to memory impairment in childhood-onset schizophrenia patients. We found evidence of disrupted morphometric structure (i.e. tissue contraction) associated with impaired memory. If further research corroborates these findings, the specific structural links to memory impairment could inform targeted clinical interventions.
We provided evidence of a new genetic mutation associated with childhood-onset schizophrenia; specifically, the duplication of the 15q13.3 chromosomal region. Our findings hold import to affected families and their genetic counselors, for whom incomplete penetrance and variable expressivity of these mutations offer substantial challenges. In previous research, the affected genes normally encode neuronal channel receptor proteins which were related to schizophrenia symptoms when mutated. Further research on gene dosage and downstream effects of this mutation may enhance understanding of contributing factors to schizophrenia and improve assessments of genetic risk.