Dale Zhou

I'm a neuroscience PhD student at the University of Pennsylvania, advised by Professor Danielle Bassett in the Complex Systems Group and co-advised by Professor Theodore Satterthwaite in the Psychiatric and Developmental Imaging Laboratory.

I did a B.Sc (honors) in psychology and B.A (honors) in philosophy at the University of Maryland, College Park, where I was co-advised in psychology by Professors Michael Dougherty and Donald Bolger, and in philosophy by Professor Peter Carruthers. I've also worked at the National Institute of Mental Health (NIMH) through the Intramural Research Training Award, where I was supervised by Dr. Judith Rapoport in the Child Psychiatry Branch.

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News
Research

I'm broadly interested in cognitive computational neuroscience, network neuroscience, computational psychiatry, developmental neuroscience, neuroimaging, imaging genetics, philosophy of mind, and philosophy of science.

Right now, I'm thinking about attention and learning, curiosity, metabolic costs of the brain, information theory, and neural signatures of ketamine in treating depression.

7 T MRI reveals hippocampal structural abnormalities associated with memory intrusions in childhood-onset schizophrenia
Dale Zhou, Siyuan Liu, Xueping Zhou, Rebecca Berman, Diane Broadnax, Peter Gochman, Judith Rapoport, Adam Thomas
Schizophrenia Research, 2018
Presented at Society for Neuroscience 2016, American College of Neuropsychopharmacology 2016, Society for Biological Psychiatry 2017, Julius Axelrod Symposium 2017

The hippocampus and its small subregions are areas of the brain that play an integral role in memory. Our study leveraged new, powerful brain imaging methods to study these small subregions and their relation to memory impairment in childhood-onset schizophrenia patients. We found evidence of disrupted structure (i.e. reduced tissue volume) associated with impaired memory. If further research corroborates these findings, the specific structural links to memory impairment could inform targeted clinical interventions.

15q13.3 duplication in two patients with childhood-onset schizophrenia
Dale Zhou, Peter Gochman, Diane Broadnax, Judith Rapoport, Kwangmi Ahn
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015
Presented at Society for Biological Psychiatry 2016

We provided evidence of a new genetic mutation associated with childhood-onset schizophrenia; specifically, the duplication of the 15q13.3 chromosomal region. Our findings hold import to affected families and their genetic counselors, for whom incomplete penetrance and variable expressivity of these mutations offer substantial challenges. In previous research, the affected genes normally encode neuronal channel receptor proteins which were related to schizophrenia symptoms when mutated. Further research on gene dosage and downstream effects of this mutation may enhance understanding of contributing factors to schizophrenia and improve assessments of genetic risk.


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